Cheng Lab


Book Chapters:


Cover Page Articles:




1. Cao W, Lu X, Cheng Z*. The advancement of human serum albumin-based molecular probes for molecular imaging. Current Pharmaceutical Design. 2015 Mar 2. [Epub ahead of print] PMID: 25732549.

2. Volotskova O, Sun C, Koh AL, Ma X, Cheng Z, Pratx G, Xing L. Cerenkov Radiation Energy Transfer (CRET) using Gold Nanoclusters for Molecular Imaging. Small. 2015, accepted and in press.

3. Chen Y, Xu L, Gong Z, Cheng Z.* Application of image processing and analysis techniques in molecular imaging. Journal of Shanghai Jiaotong University (Medical Science). March, 2015, accepted and in press.

4. Jiang L, Tu Y, Kimura RH, Habte F, Chen H, Cheng K, Shi H, Gambhir SS, Cheng Z.* 64Cu-Labeled Divalent Cystine Knot Peptide for Imaging Carotid Atherosclerotic Plaques. Journal of Nuclear Medicine. 2015 Apr 23. pii: jnumed.115.155176. [Epub ahead of print] PMID: 25908832.

5. Su X, Cheng K, Liu Y, Hu X, Meng S, Cheng Z*. PET imaging of insulin-like growth factor type 1 receptor expression with a 64Cu-labeled Affibody molecule. Amino Acids. 2015 Apr 9. [Epub ahead of print] PMID: 25854877.

6. Liu S, Zhao N, Cheng Z*, Liu H*. Amino-functionalized Green Fluorescent Carbon Dots as Fluorescence Resonance Energy Transfer Biosensor for Hyaluronidase. Nanoscale. 2015, Mar 25. [Epub ahead of print] PMID: 25807038.

7. Sun Y, Ma X, Cheng K, Wu B, Duan J, Chen H, Bu L, Zhang R, Hu X, Deng Z, Xing L, Hong X*, Cheng Z.* Strained Cyclooctyne as a Novel Molecular Platform for Construction of Multimodal Imaging Probes. Angewandte Chemie Int Ed. 2015, 127, 1-5. Article first published online: 20 MAR 2015 DOI: 10.1002/anie.201500941 (Hot paper).

8. Tu Y, Jiang L, Zhang R, Shen B, Cheng Z.* Optical molecular imaging of cardiovascular diseases. Current Molecular Imaging. March, 2014, Accepted and in press.

9. Venturin GT, Cheng Z.* Small Peptide and Protein based Molecular Probes for Neurological Diseases Imaging. Current Peptide and Protein Science. Feb, 2014. Accepted and in press.

10. Wang M, Yang Y, Fan Z, Cheng Z*, Zhu W*, Zhang A*. Pd-Catalyzed α-Selective C(sp3)-H Acetoxylation of Amides through an Unusual Cyclopalladation Mechanism. Chemical Communications.2015 Jan 21. [Epub ahead of print] PMID: 25603885.

11. James ML, Belichenko NP, Nguyen TV, Andrews LE, Ding Z, Liu H, Bodapati D, Arksey N, Shen B, Cheng Z, Wyss-Coray T, Gambhir SS, Longo FM, Chin FT. Multimodality molecular imaging of translocator protein (18kDa) in a mouse model of Alzheimer’s disease using 18F-PBR06. Journal of Nuclear Medicine. 2015;56(2):311-6. PMID: 25613536

12. Fan Q, Cheng K, Yang Z, Zhang R, Yang M, Hu X, Ma X, Bu L, Lu X, Xiong X, Huang W, Zhao H, Cheng Z.* Perylene-diimide-based nanoparticles as highly efficient photoacoustic agents for deep brain tumor imaging in living mice. Advanced Materials. 2015 Feb;27(5):843-7. PMID: 25376906. [Inside cover page article, Adv Mater. 2015 Feb;27(5):774. doi: 10.1002/adma.201570028. PMID: 25645071.]

13. Chang E, Liu H, Unterschemmann K, Ellinghaus P, Liu S, Gekeler V, Cheng Z, Berndorff D, Gambhir SS. 18F-FAZA PET imaging response tracks the reoxygenation of tumors in mice upon treatment with the mitochondrial complex I inhibitor BAY 87-2243. Clinical Cancer Research, 2015;21(2):335-46. PMID: 25381339. 


14. Fan Q, Cheng K, Hu X, Ma X, Zhang R, Yang M, Lu X, Xing L, Huang W, Cheng Z.* Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging. J Am Chem Soc. 2014, 136(43):15185-94. PMID: 25292385 (Highlighted in the Spotlights of JACS:, featured on Nature SciBX 7(43); doi :10.1038/scibx.2014.1280. Published online Nov. 6 2014).

15. Cheng K, Yang M, Zhang R, Qin C, Su X, Cheng Z*. Dumbbell Hetero-nanostructures for Dual T1 and T2-weighted Magnetic Resonance Imaging. ACS Nano. 2014; 8(10):9884-96. PMID: 25283972.

16. Carpenter CM, Ma X, Liu H, Sun C, Pratx G, Wang J, Gambhir SS, Xing L*, Cheng Z*. Improved Cerenkov Molecular Sensitivity with Beta (minus) Emitting Radiotracers. Journal of Nuclear Medicine. 2014, 55(11):1905-9. PMID: 25300598.

17. Liu Z, Yue X, Song Z, Peng X, Guo J, Ji Y, Cheng Z, Ding J, Ai J, Geng M, Zhang A. Design, synthesis and pharmacological evaluation of 2-(thiazol-2-amino)-4-arylaminopyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors. European Journal of Medicinal Chemistry. 2014;86:438-448. PMID:25200979.

18. Bu L, Shen B*, Cheng Z.* Fluorescent imaging of cancerous tissues for targeted surgery. Advanced Drug Delivery Review. 2014; 76:21-38. PMID: 25064553.

19. Wang Y, Miao Z, Ren G, Xu Y, Cheng Z.* A Novel Affibody Bioconjugate for Dual-modality Imaging of Breast Cancer, Chemical Communications. 2014;50(85):12832-5. PMID: 24927395. [Back cover page article].

20. Su X, Cheng K, Jeon J, Shen B, Liu Y, Liu H, Hu X, Meng S, Persson M, Li J, Qin C, Miao Z, Rao J, Chin FT, Wu H, Cheng Z*. Comparative Evaluation of PET Imaging of Human Epidermal Growth Factor Receptor Positive Tumor Using Two different Site-Specific 18F-labeled Affibody Protein. Molecular Pharmaceutics. 2014, 11(11):3947-56. PMID: 24972326.

21. Xiang L, Ahmad M, Hu X, Cheng Z, Xing L. Label-free Photoacoustic Cell-Tracking in Real-time. X Acoustics: Imaging Sensing. 2014; 1:18-22.

22. Wu S, Cao Q, Wang X, Cheng K, Cheng Z*. Design, Synthesis and Biological Evaluation of Mitochondria Targeted Theranostic Agents. Chemical Communications. 2014;50(64):8919-22. PMID: 24976119.

23. Hu X, Wang Q, Liu Y, Liu H, Qin C, Robinson B, Gray BD, Pak KY, Yu A*, Cheng Z.* Optical Imaging of Articular Cartilage Degeneration Using Near-Infrared Dipicolylamine Probes. Biomaterials. 2014;35(26):7511-21. PMID: 24912814.

24. Yang X, Liu H, Sun CK, Natarajan A, Hu X, Wang X, Allegretta M, Guttmann RD, Gambhir SS, Chua MS*, Cheng Z*, So SK. Imaging of hepatocellular carcinoma patient-derived xenografts using 89Zr-labeled anti-glypican-3 monoclonal antibody. Biomaterials. 2014;35(25):6964-6971. PMID: 24836949.

25. Bu L, Li R, Liu H, Feng W, Xiong X, Zhao H, Vollrath D, Shen B, Cheng Z.* In Vivo Longitudinal Molecular Imaging of Intrastriatal Transplanted RPE Cells by 18F-P3BZA PET/CT. Radiology. 2014;272(1):174-83. PMID: 24758555. [Commented by Radiology].

26. Jiang L, Kimura RH, Ma X, Tu Y, Miao Z, Shen B, Chin FT, Shi H, Cheng Z.* A Radiofluorinated Divalent Cystine Knot Peptide for Tumor PET Imaging. Molecular Pharmaceutics. 2014, 11(11):3885-92. PMID: 24717098.

27. Qin C, Liu H, Chen K, Hu X, Lan X, Zhang Y, Cheng Z.* Theranostic of Malignant Melanoma with 64CuCl2. Journal of Nuclear Medicine. 2014; 55: 812-817. PMID: 24627435.

28. Zhu X, Li J, Hong Y, Kimura RH, Liu H, Qin C, Hu X, Hayes TR, Benny P, Gambhir SS, Cheng Z*. 99mTc-Labeled Cystine Knot Peptide Targeting Integrin αvβ6 for Tumor SPECT Imaging. Molecular Pharmaceutics. 2014; 11(4): 1208-1217. PMID: 24524409.

29. Pei Z, Lan X, Cheng Z, Qin C, Xia X, Yuan H, Ding Z, He Y, Zhang Y. Multimodality Molecular Imaging to Monitor Transplanted Stem Cells for the Treatment of Ischemic Heart Disease. PLoS One. 2014;9(3):e90543. Doi:10. 1371/journal.pone.0090543. eCollection 2014. PMID: 24608323.

30. Kasten BB, Ma X, Liu H, Hayes TR, Barnes CL, Qi S, Cheng K, Bottorff SC, Slocumb WS, Wang J, Cheng Z*, Benny PD*. Clickable, hydrophilic ligand for fac-[MI(CO)3]+ (M = Re/99mTc) applied in an S-functionalized α-MSH peptide. Bioconjugate Chemistry. 2014; 25(3):579-92. PMID: 24568284.

31. Tu Y, Wan L, Zhao D, Bu L, Dong D, Yin Z, Cheng Z, Shen B. In vitro and in vivo direct monitoring of miRNA-22 expression in isoproterenol-induced cardiac hypertrophy by bioluminescence imaging. European Journal of Nuclear Medicine and Molecular Imaging. 2014; 41(5):972-84. PMID: 24504502.

32. Cheng K, Kothapalli SR, Liu H, Koh AL, Jokerst JV, Jiang H, Yang M, Li J, Levi J, Wu JC, Gambhir SS, Cheng Z.* Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects. Journal of the American Chemical Society. 2014; 136(9):3560-3571. PMID: 24495038. (Highlighted in the Spotlights of JACS)

33. Leng L, Wang Y, Zhao Q, Wang D, He NN, Feng GW, Su W, Xu Y, Han ZC, Kong DL, Cheng Z, Xiang R, Li Z. Molecular Imaging for Assessment of Mesenchymal Stem Cells Mediated Breast Cancer Therapy. Biomaterials. 2014; 35(19):5162-70. PMID: 24685267.

34. Ma X, Cheng Z, Jin Y, Liang X, Yang X, Dai Z, Tian J. SM5-1-Conjugated PLA Nanoparticles Loaded with 5-Fluorouracil for Targeted Hepatocellular Carcinoma Imaging and Therapy. Biomaterials, 2014; 35(9): 2878-2889. PMID: 24411331.

35. Seo SH, Kim BM, Joe A, Han HW, Chen X, Cheng Z, Jang ES. NIR-light-induced surface-enhanced Raman scattering for detection and photothermal/photodynamic therapy of cancer cells using methylene blue-embedded gold nanorod@SiO2 nanocomposites. Biomaterials. 2014; 35(10):3309-3318. PMID: 24424205.

36. Jiang L, Tu Y, Shi H, Cheng Z*. PET Probes beyond 18F-FDG. The Journal of Biomedical Research. 2014;28(6):435-446. PMID: 25469112

37. Ma X, Wang J, Cheng Z*. Cerenkov Radiation: A Multi-functional Approach for Biological Sciences. Frontier Physics.2014; 2:4. doi: 10.3389/fphy.2014.00004.

38. Lanza GM, Moonen C, Baker JR Jr, Chang E, Cheng Z, Grodzinski P, Ferrara K, Hynynen K, Kelloff G, Lee YE, Patri AK, Sept D, Schnitzer JE, Wood BJ, Zhang M, Zheng G, Farahani K. Assessing the barriers to image-guided drug delivery. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014; 6(1):1-14. PMID: 24339356.

39. Bu L, Ma X, Tu Y, Shen B*, Cheng Z.* Optical Image-Guided Cancer Therapy. Current Pharmaceutical Biotechnology. 2014; 14(8):723-732. PMID: 24372233.

40. Hu X, Liu Y, Qin C, Pan Z, Luo J, Yu A*, Cheng Z*. Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: In vitro and in vivo. Cancer Letters. 2014; 346(1):114-21. PMID: 24368190. [Featured on Global Medical Discovery].


41. Tu Y, Wan L, Fan Y, Bu L, Wang K, Huang T, Cheng Z, Shen B. Ischemic postconditioning-mediated miRNA-21 protects against cardiac ischemia/reperfusion injury via PTEN/AKT Pathway.  PLoS One. 2013 Oct 3;8(10):e75872. doi: 10.1371/journal.pone.0075872. PMID:24098402.

42. Liu Y, Hu X, Liu H, Bu L, Ma X, Cheng K, Li J, Tian M, Zhang H*, Cheng Z.* A Comparative Study of Radiolabeled Bombesin Analogs for the PET Imaging of Prostate Cancer Journal of Nuclear Medicine. 2013;54(12):2132-2138. PMID: 24198391. [Featured on].

43. Liu H, Liu S, Miao Z, Jiang H, Deng Z, Hong X*, Cheng Z*. A Novel Aliphatic 18F-Labeled Probe for PET Imaging of Melanoma. Molecular Pharmaceutics. 2013;10(9):3384-3391. PMID: 23927458.

44. Habte F, Ren G, Doyle TC, Liu H, Cheng Z, Paik D. Impact of a Multiple Mice Holder on Quantitation of High-Throughput MicroPET Imaging With and Without Ct Attenuation Correction. Molecular Imaging & Biology. 2013;15(5):569-75. PMID: 23479323.

45. Jiang L, Miao Z, Liu H, Ren G, Shi H, Cheng Z.* Pilot study of 177Lu-Labeled RGD-BBN heterodimeric peptide for prostate carcinoma. Nuclear Medicine Communications. 2013;34(9):909-914. PMID:23708872.

46. Tu Y, Wan L, Bu L, Zhao D, Dong D, Huang T, Cheng Z*, Shen B*. MicroRNA-22 downregulation by atorvastatin in a mouse model of cardiac hypertrophy: a new mechanism for antihypertrophic intervention. Cellular Physiology and Biochemistry. 2013;31(6):997-1008. PMID:23860036.

47. Jia L, Cheng Z, Lan Zhang L. Fluorine-18 Labeling by Click Chemistry: Multiple Probes in One Pot. Applied Radiation and Isotopes. 2013;75:64-70. PMID: 23455406.

48. Hackel BJ, Kimura RH, Miao Z, Liu H, Sathirachinda A, Chin FT, Cheng Z, Gambhir SS. 18F-Labeled Cystine Knot Peptides for PET Imaging of Integrin αvβ6. Journal of Nuclear Medicine. 2013; 54(7):1101-5. PMID:23670900.

49. Zhao P, Yang X, Qi S, Liu H, Jiang H, Hoppmann S, Cao Q, Chua M, So SK, Cheng Z.* Molecular Imaging of Hepatocellular Carcinoma Xenografts with Epidermal Growth Factor Receptor Targeted Affibody Probes. BioMed Research International. 2013;2013:759057. doi: 10.1155/2013/759057, PMID:23710458.

50. Persson M, Liu H, Madsen J, Cheng Z*, Kjaer A*. First 18F-labeled ligand for PET imaging of uPAR: In vivo studies in human prostate cancer xenografts. Nuclear Medicine and Biology. 2013;40(5):618-24.PMID: 23602763.

51. Yang M, Cheng K, Qi S, Liu H, Jiang Y, Jiang H, Li J, Chen K, Zhang H, Cheng Z.* Affibody Modified and Radiolabeled Gold-Iron Oxide Hetero-nanostructures for Tumor PET, Optical and MR Imaging. Biomaterials. 2013;34(11):2796-806. PMID: 23343632.

52. Liu H, Liu S, Miao Z, Deng Z., Shen B, Hong X, Cheng Z.* Development of 18F-labeled picolinamide probes for PET imaging of malignant melanoma. Journal of Medicinal Chemistry. 2013;56(3):895-901. PMID: 23301672.

53. Qin C, Cheng K, Chen K, Hu X, Liu Y, Lan X, Zhang Y, Liu H, Xu Y, Bu L, Su X, Zhu X, Meng S, Cheng Z.* Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging. Scientific Reports. 2013;3:1490. doi: 10.1038/srep01490. PMID:23508226.

54. Su X, Cheng K, Wang C, Xing L, Wu H, Cheng Z.* Image-guided Resection of Malignant Gliomas Using Fluorescent Nanoparticles. WIREs Nanomedicine and Nanobiotechnology. 2013;5(3):219-32. PMID: 23378052 Invited review.

55. Jiang H, Moore SJ, Liu S, Liu H, Miao Z, Cochran FV, Liu Y, Tian M, Cochran JR, Zhang H*, Cheng Z.* A novel radiofluorinated agouti-related protein for tumor angiogenesis imaging. Amino Acids. 2013; 44(2):673-681. PMID: 22945905.

56. Natarajan A, Habte F, Liu H, Sathirachinda A, Kader R, Hu H, Cheng Z, Nagamine CM, Gambhir SS. Evaluation of 89Zr-rituximab Tracer by Cerenkov Luminescence Imaging in a Humanized Transgenic Mouse Model. Molecular Imaging & Biology. 2013; 15(4):468-75. PMID: 23471750.


57. Yang Y, Shao Q, Deng R, Wang C, Teng X, Cheng K, Cheng Z, Huang L, Liu Z, Liu X, Xing B. In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles. Angewandte Chemie International Edition. 2012;51(13):3125-3129. PMID: 22241651. [Selected as "Hot Paper" and Featured as "inside cover"].

58. Gao J, Chen K, Luong R, Bouley DM, Mao H, Qiao T, Gambhir SS, Cheng Z.* A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects. Nano Letters. 2012; 12(1):281-6. PMID: 22172022. [Highlighted by NCI Alliance for Nanotechnology in Cancer, Nanotech News,; PHYS.ORG].

59. Jang ES, Shin JH, Ren G, Park MJ, Cheng K, Chen X, Wu J, Sunwoo JB*, Cheng Z.* The manipulation of natural killer cells to target tumor sites using magnetic nanoparticles. Biomaterials. 2012; 33(22):5584-92. PMID:22575830

60. Liu H, Carpenter C, Jiang H, Pratx G, Sun C, Buchin MP, Gambhir SS, Xing L*, Cheng Z.* Intraoperative Imaging of Tumors Using Cerenkov Luminescence Endoscopy: A Feasibility Experimental Study. Journal of Nuclear Medicine. 2012; 53(10):1579-84. PMID: 22904353. [This work has received significant media coverage including ScienceDaily, ACS press room, MedImaging, etc.].

61. Miao Z, Ren G, Liu H, Qi S, Wu S, Cheng Z.* PET of EGFR Expression with an 18F-Labeled Affibody Molecule. Journal of Nuclear Medicine. 2012; 53(7): 1110-8. PMID:  22689926.

62. Xu Y, Chang E, Liu H, Jiang H, Gambhir SS, Cheng Z.* Proof-of-Concept Study of Monitoring Cancer Drug Therapy with Cerenkov Luminescence Imaging. Journal of Nuclear Medicine. 2012; 53(2):312-317. PMID: 22241909. [Selected to be published on UroToday].

63. van de Ven SM, Elias SG, Chan CT, Miao Z, Cheng Z, De A, Gambhir SS. Optical Imaging with HER2-targeted Affibody Molecules can monitor Hsp90 treatment response in a breast cancer xenograft mouse model. Clinical Cancer Research. 2012; 18(4): 1073-1081. PMID: 22235098.

64. Jiang H, Kasten BB, Liu H, Qi S, Liu Y, Tian M, Barnes CL, Zhang H*, Cheng Z*, Benny PD*. M(CO)(M = Re, 99mTc) incorporation on the backbone of an α-MSH peptide using a modified-cysteine chelation strategy. Bioconjugate Chemistry. 2012;23(11):2300-12.PMID: 23110503.

65. Li J, Chen K, Liu H, Cheng K, Yang M, Zhang J, Cheng JD, Zhang Y*, Cheng Z.* An Activatable Near Infrared Fluorescent Probe for In Vivo Imaging of Fibroblast Activation Protein-alpha (FAPα). Bioconjugate Chemistry. 2012; 23(8):1704-11. PMID: 22812530.

66. Qi S, Miao Z, Liu H, Xu Y, Feng Y, Cheng Z.* Evaluation of Four Affibody based Near-infrared Fluorescent Probes for Optical Imaging of Epidermal Growth Factor Receptor Positive Tumors. Bioconjugate Chemistry. 2012; 23(6):1149-1156. PMID:  22621238 .

67. Seo J, Ren G, Liu H, Miao Z, Park M, Wang Y, Miller TM, Barron AE, Cheng Z.* In Vivo Biodistribution and Small Animal PET of 64Cu-Labeled Antimicrobial Peptoids.  Bioconjugate Chemistry. 2012; 23: 1069-1079. PMID: 22486390 [Selected by F1000,].

68. Xu Y, Huang W, Gang R, Qi S, Jiang H, Miao Z, Liu H, Lucente E, Bu L, Shen B, Barron A, Cheng Z.* A Four-Arm Star-Shaped Poly(ethylene glycol) (StarPEG) Platform for Bombesin Peptide Delivery to Gastrin-Releasing Peptide Receptors in Prostate Cancer, ACS Macro Letters. 2012, 1; 753-757. DOI: 10.1021/mz300105n

69. Yang M, Hoppmann S, Chen L, Cheng Z.* Human Serum Albumin Conjugated Biomolecules for Cancer Molecular Imaging. Current Pharmaceutical Design. 2012;18:1023-1031. PMID: 22272822.

70. Cheng K, Cheng Z.* Near Infrared Receptor-Targeted Nanoprobes for Early Diagnosis of Cancers Invited review (peer reviewed), Current Medicinal Chemistry. 2012; 19(28):4767-85. PMID: 22873665.

71. Bu L, Xie J, Chen K, Huang J, Aguilar ZP, Wang A, Sun KW, Chua MS, So S, Cheng Z, Eden HS, Shen B, Chen X. Assessment and comparison of magnetic nanoparticles as MRI contrast agents in a rodent model of human hepatocellular carcinoma. Contrast Media and Molecular Imaging. 2012; 7(4): 363-72. doi: 10.1002/cmmi.494. PMID: 22649042.

72. Xu Y, Liu H, Chang E, Jiang H, Cheng Z.* Cerenkov Luminescence Imaging (CLI) for Cancer Therapy Monitoring. Journal of Visualized Experiments. 2012;69:e4341. doi: 10.3791/4341. PMID: 23183774

73. Shambat G, Kothapalli SR, Khurana A, Provine J, Sarmiento T, Cheng K, Cheng Z, Harris J, Daldrup-Link H, Gambhir SS, Vuckovi J. A photonic crystal cavity-optical fiber tip nanoparticle sensor for biomedical applications. Applied Physics Letters. 2012, 100, 213702;

74. Carpenter CM, Sun C, Pratx G, Liu H, Cheng Z, Xing L. Radioluminescent Nanophosphors Enable Multiplexed Small-Animal Imaging. Optic Express. 2012, 20 (11):11598-11604. PMID: 22714145.

75. Parashurama N, Osullivan T, De la Zerda A, Jaggala, Cho S, Liu, H, Teed, R, Levy H, Rosenberg J, Cheng Z, Levi O, Harris, J, Gambhir SS. Continuous sensing of tumor-targeted molecular probes with a vertical cavity surface emitting laser-based biosensor. Journal of Biomedical Optics. 2012;17(11):117004. PMID: 23123976

76. Kothapalli Sri-R, Liu H, Liao JC, Cheng Z*, Gambhir SS*. Endoscopic Imaging of Cerenkov Luminescence. Biomedical Optics Express. 2012, 3(6): 1215–1225. PMID: 22741069. [Highlighted in Spot on Optics ( boe-3-6-1215)].

77. Jiang L, Miao Z, Kimura RH, Ren G, Liu HG, Silverman AP, Li PY, Gambhir SS, Cochran JR, Cheng Z.* 111In-Labeled Agouti Related Proteins for SPECT/CT Imaging of Tumor αvβ3 Integrin. Journal of Biomedicine and Biotechnology. 2012;2012:368075. doi: 10.1155/2012/368075. PMID: 22570527.

78. Hoppmann S, Qi S, Miao Z, Liu H, Jiang H, Culter CS, Bao A, Cheng Z.* 177Lu-DO3A-HSA-ZEGFR:1907: characterization as a potential radiopharmaceutical for radionuclide therapy of EGFR-expressing head and neck carcinomas. Journal of Biological Inorganic Chemistry. 2012; 17(5):7-9-718. PMID: 22418921.

79. Ren G, Webster JM, Liu Z, Zhang R, Miao Z, Gambhir SS, Syud FA, Cheng Z.* In Vivo Targeting of HER2 Positive Tumor Using 2-helix Affibody Molecules. Amino Acids. 2012; 43(1):405-13. PMID: 21984380.

80. Pei Z, Lan X, Cheng Z, Qin C, Wang P, He Y, Mghanga FP, Tian Y, Zhang Y. A multimodality reporter gene for monitoring transplanted stem cells. Nuclear Medicine and Biology. 2012;39(6):813-20. PMID: 22336371.

81. Yao Y, Jiang Y, Sheng Z, Zhang Y, An Y, Ma G, Liu N, Teng G, Cheng Z. Analysis of In Situ and Ex Vivo αvβ3 Integrin Expression during Experimental Carotid Atherogenesis. International Journal of Nanomedicine. 2012;7:641-9. PMID:22334786.


82. Sun C, Pratx G, Carpenter CM, Liu H, Cheng Z, Gambhir SS, Xing L*. Synthesis and Radioluminescence of PEGylated Eu3+-doped Nanophosphors as Bioimaging Probes. Advanced Materials. 2011,23(24):H195-9. PMID: 21557339.

83. Zavaleta CL, Hartman KB, Miao Z, James ML, Kempen P, Thakor A, Nielsen CH, Sinclair R, Cheng Z, Gambhir SS. Preclinical Evaluation of Raman Nanoparticle Biodistribution for Their Potential Use in Clinical Endoscopy Imaging. Small. 2011;7(15)2232-40. PMID: 21608124.

84. Jokerst JV, Miao Z, Zavaleta CL, Cheng Z, Gambhir SS. Affibody Functionalized Gold-Silica Nanoparticles for Raman Molecular Imaging of the Epidermal Growth Factor Receptor. Small. 2011, 7(5):625-33. PMID:  21302357.

85. Gao J, Chen K, Miao Z, Ren G, He X, Chen X, Gambhir SS, Cheng Z.* Affibody-based Nanoprobes for HER2-Expressing Cell and Tumor Imaging. Biomaterials. 2011, 32(8): 2141-2148. PMID: 21147502.

86. Xu Y, Liu H, Cheng Z.* Harnessing the Power of Radionuclides for Optical Imaging: Cerenkov Luminescence Imaging. Journal of Nuclear Medicine. 2011; 52(12):2009-18. PMID: 22080446.

87. Miao Z, Ren G, Jiang L, Liu H, Webster JM, Zhang R, Namavari M, Gambhir SS, Syud F, Cheng Z.* A Novel 18F-Labeled 2-Helix Small Protein for PET Imaging of HER2 Positive Tumor. European Journal of Nuclear Medicine and Molecular Imaging. 2011; 38(11):1977-84. PMID: 21761266.

88. Liu S, Liu H, Jiang H, Zhang H, Cheng Z.* One-Step Radiosynthesis of 18F-AlF-NOTA-RGD2 for Tumor Angiogenesis PET imaging. European Journal of Nuclear Medicine and Molecular Imaging. 2011; 38(9):1732-41. PMID: 21617974.

89. Jiang L, Miao Z, Kimura RH, Liu HG, Cochran JR, Culter CS, Bao A, Li PY*, Cheng Z.* Preliminary Evaluation of 177Lu-Labeled Knottin Peptides for Integrin Receptors-Targeted Radiotherapy. European Journal of Nuclear Medicine and Molecular Imaging. 2011, 38(4):613-22. PMID: 21153409.

90. Chang E, Liu S, Gowrishankar G, Yaghoubi S, Wedgeworth JP, Chin F, Berndorff D, Gekeler V, Gambhir SS, Cheng Z.* Reproducibility Study of 18F-FP-PRGD2 Uptake in Murine Models of Human Tumor Xenografts. European Journal of Nuclear Medicine and Molecular Imaging. 2011, 38(4):722-30. PMID: 21125268.

91. Jiang H, Cheng Z, Tian M, Zhang H. In Vivo Imaging of Embryonic Stem Cell Therapy. European Journal of Nuclear Medicine and Molecular Imaging. 2011, 38(4):774-84. PMID: 21107558. Invited review.

92. Hoppmann S, Miao Z, Liu S, Liu H, Bao A, Cheng Z.* Radiolabeled Affibody-Human Serum Albumin Bioconjugates for HER2 Positive Cancer Targeting. Bioconjugate Chemistry. 2011, 22(3): 413-21. PMID: 21299201. [Cover page article].

93. Yang Y, Aw J, Chen K, Padmanabhan P, Hou Y, Cheng Z*, Xing B*. Enzyme-Responsive Multifunctional Magnetic Nanoparticles for Tumor Intracellular Drug Delivery and Imaging. Chemistry An Asian Journal. 2011, 6(6):1381-1389. PMID: 21548100. [Cover page article].

94. Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS*, Bogyo M*, Cheng Z.* Non-Invasive Imaging of Cysteine Cathepsin Activity in Solid Tumors Using a 64Cu-Labeled Activity-Based Probe. Plos One. 2011, 6(11): e28029. doi:10.1371/journal.pone.0028029. PMID:22132198.

95. Kimura RH, Jones DS, Jiang L, Miao Z, Cheng Z*, Cochran JR*. Functional mutation of multiple solvent-exposed loops of the Ecballium elaterium trypsin inhibitor-II cystine knot miniprotein. Plos One. 2011, 6(2): e16112. doi:10.1371/journal.pone.0016112. PMID: 21364742.

96. Liu S, Shen B, Chin F, Cheng Z.* Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging. Invited review (peer reviewed), Current Organic Synthesis. 2011; 8(4): 584-592.

97. Wu S, Chang E, Cheng Z.* Molecular Probes for Bioluminescence Imaging. Invited review (peer reviewed), Current Organic Synthesis. 2011; 8(4): 488-497.

98. Miao Z, Levi J, Cheng Z.* Protein Scaffolds Based Molecular Probes for Cancer Molecular Imaging. Amino Acids. 2011, 41(5): 1037-1047. PMID: 20174842. Invited review.

99. Liu S, Liu H, Ren G, Kimura RH, Zhang X, Jiang L, Cochran JR, Cheng Z.* PET imaging of integrin expression using fluorine-18 labeled knottin peptides. Theranostics. 2011;1:403-412. PMID: 22211146.

100. Zhang X, Liu H, Miao Z, Kimura R, Fan F, Cheng Z.* Macrocyclic Chelator Assembled RGD Multimers for Tumor Targeting. Bioorganic Medicinal Chemistry Letters. 2011, 21(11): 3423-3426. PMID: 21524578.

101. Wang J, Xie J, Zhou X, Cheng Z, Gu N, Teng G, Hu Q, Zhu F, Chang S, Zhang F, Lu G, Chen X. Ferritin Enhances SPIO Tracking of C6 Rat Glioma Cells by MRI. Molecular Imaging & Biology. 2011, 13(1):87-93. PMID: 20440566.

102. Jang ES, Won JH, Kim YW, Cheng Z, Choy JH. Dynamic transition between Zn-HDS and ZnO; growth and dissolving mechanism of dumbbell-like ZnO bipod crystal. CrystEngComm. 2011; 13(2), 546-552.

103. Neofytou E, Chang E, Patlola B, Kimura N, Lijkwan M, Joubert L-M, Rajadas J, Wu J, Chen X, Robbins RC, Gambhir SS, Cheng Z, Beygui RE. Enhanced Vascularization of Tissue-Engineered Adipose Tissue-Derived Stem Cell on Three Dimensional Scaffolds. Journal of Biomedical Materials Research Part A. 2011;98(3):383-93. PMID: 21630430.


104. He X, Gao J, Gambhir SS, Cheng Z.* Near-infrared fluorescent nanoprobes for cancer molecular imaging: current status and future perspectives. Trends in Molecular Medicine. 2010; 16(12):574-83. PMID: 20870460. Invited review.

105. Huang J, Bu L, Xie J, Chen K, Cheng Z, Li X, Chen X. Effects of Nanoparticle Size on Cellular Uptake and Liver MRI with Polyvinylpyrrolidone-Coated Iron Oxide Nanoparticles. ACS Nano.2010, 4(12):7151-7160. PMID: 21043459.

106. Smith BR, Cheng Z, De A, Rosenberg J, Gambhir SS. Dynamic visualization of RGD-quantum dot binding to tumor neovasculature and extravasation in multiple living mouse models using intravital microscopy. Small.2010, 6(20):2222-9. PMID: 20862677. [Cover Page Article].

107. Liu H, Zhang X, Xing B, Han P, Gambhir SS, Cheng Z.* Radiation Luminescence Excited Quantum Dots for In Vivo Multiplexed Optical Imaging. Small. 2010, 6(10); 1087-1091. PMID: 20473988. [Inside Cover Page Article].

108. Gao J, Chen K, Xie R, Xie J, Lee S, Cheng Z, Peng X, Chen X. Ultrasmall near-infrared non-cadmium quantum dots for in vivo tumor imaging. Small. 2010, 6(2):256-261. PMID: 19911392.

109. Nielsen CH, Kimura RH, Withofs N, Tran PT, Miao Z, Cochran J, Cheng Z, Felsher D, Willmann JK, Kjær A, Gambhir SS. PET Imaging of Tumor Neovascularization in a Transgenic Mouse Model Using a Novel 64Cu-DOTA-Knottin Peptide. Cancer Research. 2010; 70(22):9022-30. PMID: 21062977.

110. Jiang L, Kimura RH, Miao Z, Silverman AP, Ren G, Liu HG, Li, P, Gambhir SS, Cochran JR, Cheng Z.* Evaluation of a 64Cu-labeled cystine-knot peptide based on Agouti-Related protein for PET of tumors expressing αvβ3 integrin. Journal of Nuclear Medicine. 2010, 51(2): 251-258.  PMID: 20124048.

111. Huang J, Xie J, Chen K, Bu L, Lee S, Cheng Z, Li X, Chen X. HSA Coated MnO Nanoparticles with Prominent MRI Contrast for Tumor Imaging. Chemical Communication. 2010; 46:6684-6. PMID: 20730157.

112. He X, Wang KM, Cheng Z.* In vivo near-infrared fluorescence imaging of cancer with nanoparticles-based probes. WIREs Nanomedicine and Nanobiotechnology. 2010: 2(4): 349-366. PMID: 20564463. Invited review.  [One of The Top Ten Cited WNAN Articles].

113. Ren G, Liu S, Liu H, Miao Z, Cheng Z.* Radiofluorinated Rhenium Cyclized α-MSH Analogs for PET Imaging of Melanocortin Receptor 1. Bioconjugate Chemistry. 2010, 21(12):2355-60. PMID: 21073170.

114. Miao Z, Ren G, Liu H, Jiang L, Cheng Z.* Small-Animal PET Imaging of Human Epidermal Growth Factor Receptor 1 Positive Tumor with a 64Cu Labeled Affibody Protein. Bioconjugate Chemistry.2010, 21(5): 947-54. PMID: 20402512.

115. Kimura RH, Miao Z, Cheng Z, Gambhir SS, Cochran JR. A Dual-Labeled Knottin Peptide for PET and Near-Infrared Fluorescence Imaging of Integrin Expression in Living Subjects. Bioconjugate Chemistry. 2010, 21(3), 436-444. PMID: 20131753.

116. Gao J, Chen K, Xie RG, Xie J, Yang YJ, Cheng Z, Peng XG, Chen XY. In vivo tumor-targeted fluorescence imaging using near-infrared non-cadmium quantum dots. Bioconjugate Chemistry. 2010, 21(4):604-609. PMID: 20369817.

117. Liu HG, Ren G, Miao Z, Zhang XF, Tang X, Han PZ, Gambhir SS, Cheng Z.* Molecular Optical Imaging with Radioactive Probes. PLoS One. 2010, 5(3): e9470. PMID: 20208993. [Highlighted by SNM Newsletter, JNM, 2010; 51(5), 28N].

118. Liu H, Ren G, Zhang X, Chen L, Han P, Cheng Z.* Optical Imaging of Reporter Gene Expression Using a Positron-Emission-Tomography Probe. Journal of Biomedical Optics. 2010. 15(6): 060505. PMID: 21198146.

119. Miao Z, Ren G, Liu H, Jiang L, Cheng Z.* Cy5.5 labeled Affibody Molecule for Near-infrared Optical imaging of Epidermal Growth Factor Receptor1 expression. Journal of Biomedical Optics. 2010, 15(3): 036007. PMID: 20615009.

120. Ren G, Pan Y, Cheng Z.* Molecular Probes for Malignant Melanoma Imaging. Current Pharmaceutical Biotechnology. 2010. 11(6):590-602. PMID: 20497118. Invited review.

121. Gao J, Chen X, Cheng Z. Near-infrared Quantum Dots as Optical Probes for Tumor Imaging. Current Topics in Medicinal Chemistry. 2010, 10(12):1147-57. PMID: 20388111. Invited review.

122. Jang ES, Won JH, Kim YW, Cheng Z, Choy JH. Synthesis of porous and nonporous ZnO nanobelt, multipod, and hierarchical nanostructure from Zn-HDS. Journal of Solid State Chemistry. 2010. 183(8); 1835-1840.

123. Cheng Z*, De Jesus OP, Kramer DJ, De A, Webster JM, Gheysens O, Levi J, Namavari M, Wang S, Park JM, Zhang R, Liu H, Lee B, Syud FA, Gambhir SS. 64Cu-labeled affibody molecules for imaging of HER2 expressing tumors. Molecular Imaging & Biology. 2010, 12(3): 316-324. PMID: 19779897.


124. Schipper ML, Iyer G, Koh AL, Cheng Z, Ebenstein Y, Keren S, Bentolila LA, Zerda A, Li J, Smith BR, Rao J, Chen X, Wu AM, Sinclair R, Weiss SS, Gambhir SS. Particle size, surface coating, and PEGylation influence the biodistribution of quantum dots in living mice. Small. 2009, 5(1): 126-134. PMID: 19051182.

125. Kimura RH, Cheng Z, Gambhir SS, Cochran JR. Engineered knottin peptides: a new class of agents for imaging integrin expression in living subjects. Cancer Research. 2009, 69(6): 2435-2442. PMID: 19276378.

126. Benoit MR, Mayer D, Barak Y, Chen IY, Hu W,  Cheng Z, Wang SX, Spielman DM, Gambhir SS, Matin A. Visualizing implanted tumors in mice with magnetic resonance imaging using magnetotactic bacteria. Clinical Cancer Research. 2009, 15(16): 5170-5177. PMID: 19671860.

127. Ren G, Zhang R, Liu Z, Webster JM, Miao Z, Gambhir SS, Syud FA, Cheng Z.* A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression. Journal of Nuclear Medicine. 2009, 50(9): 1491-1499. PMID: 19690041. [Journal of Nuclear Medicine's 2009 Best Basic Science Paper, Featured on as well].

128. Ren G, Miao Z, Liu H, Jiang L, Limpa-Amara N, Mahmood A,Gambhir SS, Cheng Z.* Melanin-targeted preclinical PET imaging of melanoma metastasis. Journal of Nuclear Medicine. 2009, 50(10): 1692-1699. PMID: 19759116. [Featured on].

129. Ren G, Liu Z, Miao Z, Liu H, Subbarayan M, Chin FT, Zhang L, Gambhir SS, Cheng Z.* PET of malignant melanoma using 18F-labeled metallopeptides. Journal of Nuclear Medicine. 2009, 50(11): 1865-1872. PMID: 19837749.

130. Shao Q, Jiang T, Ren G, Cheng Z*, Xing B*. Photoactivatable caged bioluminescent probes for luciferase activity measurement. Chemical Communications. 2009, 15: 4028-4030. [Hot article of the issue, and Featured in Analytica-World & Bionity, Highlighted in ChemInform Weekly News].

131. Miao Z, Ren G, Liu H, Jiang L, Kimura RH, Cochran JR, Gambhir SS, Cheng Z.* An engineered knottin peptide labeled with 18F for PET imaging of αvβ3 integrin expression. Bioconjugate Chemistry. 2009, 20(12):2342-2347. PMID: 19908826. [Highlighted by SNM Newsletter, JNM, 2010; 51(1), 18N].

132. Namavari M, Cheng Z, Zhang R, De A, Levi J, Hoerner JK, Yaghoubi SS, Syud FA, Gambhir SS. A novel method for direct site-specific radiolabeling of peptides using [18F]FDG. Bioconjugate Chemistry. 2009, 20(3): 432-436. PMID: 19226160.

133. Webster JM, Zhang R, Gambhir SS, Cheng Z*, Syud FA*. Engineered two-helix small proteins for molecular recognition. ChemBioChem. 2009, 10(8): 1293-1296. PMID: 19422008

134. Jiang L, Schipper ML, Li P, Cheng Z.* 123I labeled metaiodobenzylguanidine for diagnosis of neuroendocrine tumors. Reports in Medical Imaging. 2009, 2: 79-89. Invited review.

135. Liu X, Xiong Z, Lee S, Levi J, Yaghoubi S, Biswal S, Gambhir SS, Cheng Z.* Near-infrared fluorescent deoxyglucose analog for optical imaging of experimental arthritis. Journal of Innovative Optical Health Sciences. 2009, 2: 179-187.


136. De la Zerda A, Zavaleta C, Keren S, Vaithilingam S, Bodapati S, Liu Z, Levi J, Ma T, Oralkan O, Cheng Z, Chen X, Dai H, Khuri-Yakub B, Gambhir SS. Photoacoustic molecular imaging in living mice utilizing targeted carbon nanotubes. Nature Nanotechnology. 2008, 3: 557-562. [Cover page article, this work has received significant media coverage in radio broadcasts (KCBS Radio, KGO Radio, KQED Radio) and in the press (Washington Post, U.S. News, Forbes, MSN Health, Springfield News-Sun, Medical Health Articles, Stay Healthy News, Your Total Health, Yahoo! News, Yahoo! Health, Dr. Koop].

137. Keren S, Zaveleta C, Cheng Z, de La Zerda A., Gheysens O, Gambhir SS. Noninvasive molecular imaging of small living subjects using Raman spectroscopy. PNAS. 2008; 105(15):5844-5849. PMID: 18378895. [This work has received significant media coverage by worldwide media including the front page of the San Francisco Chronicle, US News & World Report, Photonics, the Telegraph in India].

138. Zavaleta C, de la Zerda A, Liu Z, Keren S, Cheng Z, Schipper M, Chen X, Dai H, Gambhir SS. Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes. Nano Letters. 2008;8(9):2800-2805. PMID: 18683988.

139. Smith BR, Cheng Z, De A, Koh AL, Gambhir SS. Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature. Nano Letters. 2008; 8(9): 2599-2606. PMID: 18386933. [Cover page article].

140. Cheng Z, Padilla De Jesus O, Namavari M, De A, Levi J, Webster JM, Zhang R, Lee B, Syud FA, Gambhir SS. Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules. Journal of Nuclear Medicine. 2008; 49(5):804-813. PMID: 18413392.

141. Willmann JK, Cheng Z, Davis C, Lutz AM, Schipper ML, Nielsen CH, Gambhir SS. Targeted microbubbles for imaging tumor angiogenesis: assessment of whole-body biodistribution with dynamic microPET Imaging in mice. Radiology. 2008, 249(1): 212-219. PMID: 18695212.

142. Namavari M, Padilla De Jesus O, Cheng Z, De A, Kovacs E, Levi J, Wang S, Zhang R, Hoerner J, Grade H, Syud FA, Gambhir SS. Direct site-specific Radiolabeling of an Affibody  protein with  [18F]fluorobenzaldehyde via oxime chemistry. Molecular Imaging & Biology. 2008;10(4):177-181. PMID: 18481153.


143. Levi J, De A, Cheng Z, Gambhir SS. Bisdeoxycoelenterazine derivatives for improvement of bioluminescence resonance energy transfer assays. Journal of the American Chemical Society. 2007; 129(39): 11900-11901. PMID: 17850082.

144. Cheng Z*, Zhang L, Graves EE, Xiong ZM, Dandekar M, Chen X, Gambhir SS. Small-animal PET of melanocortin 1 receptor expression using a 18F-labeled alpha-melanocyte-stimulating hormone analog. Journal of Nuclear Medicine. 2007; 48(6): 987-994. PMID: 17504880.

145. Schipper ML, Cheng Z, Lee SW, Bentolila LA, Iyer G, Rao J, Chen X., Wu AM, Weiss SS, Gambhir SS. MicroPET-based biodistribution of quantum dots in living mice. Journal of Nuclear Medicine. 2007; 48(9): 1511-1518. PMID: 17704240.

146. Cheng Z*, Xiong Z, Subbarayan M, Chen X, Gambhir SS. 64Cu-labeled alpha-melanocyte-stimulating hormone analog for microPET imaging of melanocortin 1 receptor expression. Bioconjugate Chemistry. 2007; 18(3): 765-772. PMID: 17348700.

147. Levi J, Cheng Z, Gheysens O, Patel M, Chan C, Wang Y, Namavari M, Gambhir SS. Fluorescent fructose derivatives for imaging breast cancer cells. Bioconjugate Chemistry. 2007; 18(3): 628-634. PMID: 17444608.

148. Niu G, Xiong ZM, Cheng Z, Cai W, Gambhir SS, Xing L, Chen X. In vivo bioluminescence tumor imaging of RGD peptide-modified adenoviral vector encoding firefly luciferase reporter gene. Molecular Imaging & Biology. 2007; 9(3): 126-134. PMID: 17297551.

Before 2007

149. Xiong ZM, Cheng Z, Zhang XZ, Patel M, Wu JC, Gambhir SS, Chen X. Imaging chemically modified adenovirus for targeting tumor expressing integrin αvβ3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. Journal of Nuclear Medicine. 2006;47(1): 130-139. PMID: 16391197. [Cover page article].

150. Cheng Z, Levi J, Xiong ZM, Gheysens O, Keren S, Chen X, Gambhir SS. Near-infrared fluorescent deoxyglucose analogue for tumor optical imaging in cell culture and living mice. Bioconjugate Chemistry. 2006; 17(3): 662-669. PMID: 16704203.

151. Cheng Z, Mahmood A, Li H, Davison A, Jones AG. [99mTcOAADT]-(CH2)2-NEt2: a potential small-molecule single-photon emission computed tomography probe for imaging metastatic melanoma. Cancer Research. 2005; 65(12): 4979-4986. PMID: 15958536. [Priority Reports].

152. Cheng Z, Wu Y, Xiong ZM, Gambhir SS, Chen X. Near-infrared fluorescent RGD peptides for optical imaging of integrin αvβ3 expression in living mice. Bioconjugate Chemistry. 2005; 16(6): 1433-1441. PMID: 16287239.

153. Tseng JR, Dandekar M, Subbarayan M, Cheng Z,  Park JM, Louie S, Gambhir SS. Reproducibility of 3'-deoxy-3'-18F-fluorothymidine microPET studies in tumor xenografts in mice. Journal of Nuclear Medicine.2005; 46(11): 1851-1857. PMID: 16269599.

154. Wu Y, Zhang XZ, Xiong ZM, Cheng Z, Fisher DR, Liu S, Gambhir SS, Chen X. MicroPET imaging of glioma integrin avb3 expression using 64Cu-labeled tetrameric RGD peptide. Journal of Nuclear Medicine.2005; 46(10): 1707-1718. PMID: 16204722.

155. Cheng Z, Winant RC, Gambhir SS. A new strategy to screen molecular imaging probe uptake in cell culture without radiolabeling using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of Nuclear Medicine. 2005; 46(5): 878-886. PMID: 15872363.

156. Cheng Z, Subbarayan M, Chen X, Gambhir SS. Synthesis of (4-[18F]fluorophenyl)-triphenylphosphonium as a potential imaging agent for mitochondrial dysfunction. Journal of Labelled Compound & Radiopharmaceuticals. 2005; 48: 131–137.

157. Cheng Z, Chen J, Quinn TP, Jurisson SS. Radioiodination of rhenium cyclized alpha-melanocyte-stimulating hormone resulting in enhanced radioactivity localization and retention in melanoma. Cancer Research. 2004; 64(4):1411-1418. PMID: 14973076.

158. Cheng Z, Chen J, Miao Y, Owen NK,  Quinn TP, Jurisson SS. Modification of the structure of a metallopeptide: synthesis and biological evaluation of 111In-labeled DOTA-conjugated rhenium-cyclized alpha-MSH analogues. Journal of Medicinal Chemistry. 2002; 45(14): 3048-3056. PMID: 12086490.

159. Chen J, Cheng Z, Miao Y, Jurisson SS, Quinn TP. Alpha-melanocyte-stimulating hormone peptide analogs labeled with technetium-99m and indium-111 for malignant melanoma targeting. Cancer. 2002; 94(4 Suppl): 1196-1201. PMID: 11877745.

160. Chen J, Cheng Z, Owen NK, Hoffman TJ, Miao Y, Jurisson SS, Quinn TP. Evaluation of an 111In-DOTA-rhenium cyclized alpha-MSH analog: a novel cyclic-peptide analog with improved tumor-targeting properties. Journal of Nuclear Medicine. 2001; 42(12): 1847-1855. PMID: 11752084.

161. Chen J, Cheng Z, Hoffman TJ, Jurisson SS, Quinn TP. Melanoma-targeting properties of 99mtechnetium-labeled cyclic alpha-melanocyte-stimulating hormone peptide analogues. Cancer Research. 2000; 60(20), 5649-5658. PMID: 11059756.

162. Cheng Z, Lin QF, Jin XH. Quality control studies of Tc-99m-DTPA-octreotide by RP-HPLC. Journal of Radioanalytical and Nuclear Chemistry. 1998; 236(1-2): 97-101. 

163. Bai HS, Jin XH, Fan HQ, Du J, Wang F, Chen DM, Cheng Z, Study on analysis of Sm-153-EDTMP stability in vitro and in vivo by HPLC. Journal of Radioanalytical and Nuclear Chemistry. 1998; 236(1-2): 87-95. 

164. Wang F, Fan HQ, Chen DM, Bai HS, Cheng Z. HPLC analysis of radiolabeled octreotide. Journal of Radioanalytical and Nuclear Chemistry.1998; 236(1-2): 205-207.

165. Bai HS, Cheng Z, Jin XH, Du J, Wang F, Chen D, Fan H, Zhang NF, Yang L, Li ZR. Preparation of Sm-153-resin micorosphere and determination of femoral head blood flow of rabbits. Journal of Isotopes.1998; 11(1): 39-43.

166. Fan HQ, Wang F, Jin XH, Cheng DM, Bai HS, Cheng Z, Du J. Labeling conditions studies of Tyr3-octreotide with 131I and its biodistribution in mouse. Journal of Isotopes. 1998; 11(1), 29-33.

167. Cheng Z, Lin QF, Jin XH. Development of 99mTc-DTPA-octreotide somatostaton receptor imaging agent. I. studying of labeling conditions. Journal of Isotopes.1997; 10(3): 150-157.

168. Bai HS, Du J, Cheng Z, Fan HQ, Wang F, Chen DM, Jin XH. Preparation of Sm-153-Cl2MDP and preliminary animal test. Nuclear Techniques. 1997; 20(11): 699-701.

169. Bai HS, Jin XH, Du J, Wang F, Chen DM, Fan HQ, Cheng Z. Preparation of 166Ho-EDTMP-hydroxyapatite for radiation synovectomy. Nuclear Techniques. 1997; 20(11): 691-695.

170. Chen DM, Jin XH, Du J, Wang F, Bai HS, Xu H, Cheng Z, Chen S, Qi X, Zhao X, Lu X. Preliminary study on a potential tumor radiotherapy agent: 186Re(V)-DMSA. Journal of Isotopes. 1997; 10(2): 109-112.

171. Wang F, Fan HQ, Xaio L, Wang YS, Jin XH, Chen DM, Bai HS, Cheng Z, Du J. Labeling study on In-111-octreotide and primary animal tests. Journal of Isotopes. 1997; 10(1): 16-20.