Cheng Lab

Optical Imaging Techniques

Recently, we and others have found that a variety of radioactive materials (b+ and b- emitters) could be detected by OI techniques. It has been successfully demonstrated that radioactive molecular probes such as 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), Na18F, Na131I, 90YCl3 and 90Y labeled tumor targeting peptides could be non-invasively imaged in small animals by optical imaging instruments (Figure 1 and 2). This is mainly attributed to the ability of radioactive materials to produce low energy visible photons (1.2 - 3.1 eV, 400 - 1000 nm) associated with Cerenkov radiation.

Optical imaging of Cerenkov radiation has emerged as an important and promising strategy for molecular imaging research. It nicely bridges nuclear imaging and optical imaging. This technique could be particularly useful in the preclinical research such as radiopharmaceutical development and drug screening. It may also find applications in clinical cancer diagnosis. In our research, we also demonstrated that the radioactive luminescent light at visible and NIR window (1.2 - 3.1 eV, 400 - 1000 nm) could serve as an internal source for illumination of many different fluorophores such as QDs, and the resulting fluorescent emissions could then be used for optical imaging in living subject (Figure 3).

Please read our publications for more information: